Document Type : Research Paper
Authors
1 Department of Animal Science, Facuity of Agriculture, Shahrekord University. Shahrekord
2 Department of Animal Science, Faculty of Agriculture, Shahrekord University, Shahrekord- Iran.
3 Animal Science Dept. University of Shahrekird, Iran.
4 Department of animal science Shahrekord University Shahrekord Iran
Abstract
In the present study, the antioxidant and antihyperlipidemic effects of atorvastatin and liquorice root were investigated in broiler chickens raised at high altitude. The experiment was conducted in the form of a completely randomized design with 4 treatments, 6 repetitions, treatments include basic diet (control), treatment 2 (basic diet + 20 mg/kg of atorvastatin), treatments 3 and 4, respectively, basic diet + 3.75 and 7.5 g/kg of liquorice root powder. The test results showed that weight gain and feed conversion ratio were significantly improved by adding atorvastatin and liquorice root powder (7.5 g) (P<0.05). The inclusion of atorvastatin and liquorice decreased the expression of the key liver lipogenic enzymes acetyl-CoA carboxylase and hydroxymethylglutaryl coenzyme A reductase compared to the control (P<0.05), causing a significant decrease in abdominal fat, liver weight And the right ventricle was revived according to the weight. On the other hand, there was a decrease in the concentration of malondialdehyde, triacylglycerol and low density lipoproteins and an increase in the concentration of nitric oxide compared to the control group (P<0.05). With the increase in liquorice consumption level, the telomere length of liver DNA increased. In general, the addition of atorvastatin and liquorice herb moderated lipogenesis, increased antioxidant response, improved cardiopulmonary function, and reduced telomere DNA degradation in broilers under hypoxic conditions. According to the findings of this research, the use of 20 mg/kg of atorvastatin and 7.5 g/kg of liquorice root powder of diet improves performance and reduces the traits related to fat in broiler chickens.
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